The International Council on Nanotechnology

Towards Predicting Nano-Biointeractions

Today, the International Council on Nanotechnology released the findings of two workshops designed to identify the research needed to predict nanomaterial impacts on living systems and the environment. This represents the first effort to tackle the grand challenge of predicting nanomaterial impacts on human health and the environment.

World-renowned experts in nanomaterial synthesis and characterization worked side-by-side with their counterparts in toxicology and environmental impacts to develop a prioritized agenda for predicting nanomaterials' biological and environmental impacts.

The breadth of expertise at these workshops was astonishing. But bringing together diverse experts to work on shared challenges is standard operating procedure for ICON.

A sampling of the findings of the 79-page report includes:
  • Tools and models must be developed that can describe the dynamic nature of nanomaterials throughout their lifestyle.

  • A set of screening tools is needed to correlate the functional properties of nanomaterials with their potential for biological interaction.

  • Exposure assessment studies are needed to lead to predictions about physicochemical properties and their implications for net dose.
  • Quantitative models are needed to describe how the physicochemical properties of nanoparticles control the nature and extent of biomolecular interactions at their surface.
  • Dose and dose rate may need to be validated independently for nanomaterials.
  • Specific research designed to develop better biomarkers, or sets of biomarkers, is essential to address the vast diversity of nanoparticle types and to develop strong correlative models for predicting in vivo data based on in vitro results.

Here's what some people are saying about the report:

Professor Vicki Colvin, Executive Director, ICON:
"The systematic approach taken in these workshops will provide a solid foundation for further research, enable risk management and guide commercial development."

Dr. Andrew Maynard, Chief Science Advisor to the Project on Emerging Nanotechnologies and member of ICON's Executive Committee:
"The broad participation in these workshops represents the kind of decision-making process that is essential to determining how nanotechnology can be used safely."

Dr. Sally Tinkle, Senior Science Advisor to the Acting Director at the National Institute of Environmental Health Sciences, National Institutes of Health:
"Independent efforts such as this one add tremendous value to the work we’re doing at the governmental level. The ICON report provides a detailed roadmap for addressing a specific grand challenge and can inform the federal strategy."

Dr. Gérard Rivière, President of the European Committee for Standardization and Research:
"These workshops demonstrated an impressive commitment to international cooperation and harmonization, especially considering the collective necessity to develop and use standardized materials and reference methods operational at the nanoscale. Such broad engagement will be vital to addressing nanotechnology’s impacts in the future."

Intel: Paolo Gargini, Intel Fellow and Director of Technology Strategy: (pdf)
"Intel supports the broad communication of this report to enable prioritization of international research nanotechnology. While companies and countries will compete in the commercialization of nanotech in the area of EHS, cooperative and collaborative research should be the cornerstone."

There are many outstanding challenges and a healthy skepticism about the value of predictive modeling, so let's hear it:

What do you think are the most pressing challenges for nanotechnology?

1 comment:

Dale ritter said...

Advancement in predictions of nan-biointeractions depend on the atomic model structural wavefunction, since that picoscale window is the data horizon of nanostructural features which holds the solutions to the strict risk assessment task.
Quantum and relativistic factors loom large in these definitions, leading to application of exact mathematical modeling process criteria.
The atom's RQT (relative quantum topological) data point imaging function is built by combination of the relativistic Einstein-Lorenz transform functions for time, mass, and energy with the workon quantized electromagnetic wave equations for frequency and wavelength. The atom labeled psi (Z) pulsates at the frequency {Nhu=e/h} by cycles of {e=m(c^2)} transformation of nuclear surface mass to forcons with joule values, followed by nuclear force absorption. This radiation process is limited only by spacetime boundaries of {Gravity-Time}, where gravity is the force binding space to psi, forming the GT integral atomic wavefunction. The expression is defined as the series expansion differential of nuclear output rates with quantum symmetry numbers assigned along the progression to give topology to the solutions.
Next, the correlation function for the manifold of internal heat capacity particle 3D functions condensed due to radial force dilution is extracted; by rearranging the total internal momentum function to the photon gain rule and integrating it for GT limits. This produces a series of 26 topological waveparticle functions of five classes; {+Positron, Workon, Thermon, -Electromagneton, Magnemedon}, each the 3D data image of a type of energy intermedon of the 5/2 kT J internal energy cloud, accounting for all of them.
Those values intersect the sizes of the fundamental physical constants: h, h-bar, delta, nuclear magneton, beta magneton, k (series). They quantize nuclear dynamics by acting as fulcrum particles. The result is the picoyoctometric, 3D, interactive video atomic model data imaging function, responsive to keyboard input of virtual photon gain events by relativistic, quantized shifts of electron, force, and energy field states and positions.
Now a nano-biointeraction modeling infotool for strict safety standard definitions is found, with automated or semiautomated force and energy interaction functions.
Images of the h-bar magnetic energy waveparticle of ~175 picoyoctometers are available online at http://www.symmecon.com with the complete RQT atomic modeling guide titled The Crystalon Door, copyright TXu1-266-788. TCD conforms to the unopposed motion of disclosure in U.S. District (NM) Court of 04/02/2001 titled The Solution to the Equation of Schrodinger.

(C) 2009, Dale B. Ritter, B.A.